The ACPA IgM fine specificity differs from the ACPA IgG antigen-recognition profile

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The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA

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CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis

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A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis

BACKGROUND Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWA...

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Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein...

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INTRODUCTION The aim of this study was to examine seroconversion and the relationship with age and inflammation of autoantibodies in a large group of patients attending an outpatient rheumatology clinic. METHODS Levels of antibodies to citrullinated proteins/peptides (ACPAs) and IgM rheumatoid factor (IgM-RF) were determined in 22,427 samples collected from 18,658 patients. The diagnosis was ...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2012

ISSN: 0003-4967,1468-2060

DOI: 10.1136/annrheumdis-2011-201234.4